Sheng-Chung Lee

Sheng-Chung Lee Ph.D.

Professor Emeritus

Research interest:
Regulation of Gene Expression

Institute of Molecular Medicine



Compensatory mechanisms between ubiquitin proteasome system (UPS) and autophagy catabolic pathways


My research is focusing on regulations of UPS and autophagy by the interplays of p97/VCP, PP2A, SIK2, CaMK1 and PME-1. Other proteins such as AMPK, JNK, mTOR, SREBP, HDAC6, Hsp90, p62/SQSTM1, PKCand ataxin-3 are also included in these studies.


Ph.D., Biochemistry and Biophysics, University of California, Davis (1972)
Postdoctoral fellow, Biochemistry, Brandeis University (1973-1974); Stanford University (1975-1980)
BS, Agriculture Chemistry, National Taiwan University (1967)

Associate professor, Institute of Biochemical Sciences, National Taiwan University (1980-1982)
Associate member, Institute of Biological Chemistry, Academia Sinica (1982-1983)
Associate professor, Institute of Clinical Medicine, National Taiwan University (1982-1984)
Member, Institute of Biological Chemistry, Academia Sinica (1983-present)
Professor, Institute of Clinical Medicine, National Taiwan University (1984-1992)
Professor, Institute of Molecular Medicine, National Taiwan University (1992-present)

Li-Ping Tu

Chia-Wei Lee, Chun-Hung Chen, Chia-Ling Hsieh, Fu-Chia Yang, Hsing-Yun Chang, Su-Hui Su

Liu H., B.C. Tan, K.H. Tseng , C.P. Chuang, C.W. Yeh, K.D. Chen, S.C. Lee, B.Y. Yung. 2007. Nucleophosmin acts as a novel AP2alpha-binding transcriptional corepressor during cell differentiation. EMBO Rep. 8(4):394-400.

Chen, J.S., W.C. Cheng, H.C. Lien, S.W. Wu, H.H. Hsu, S.C. Lee, and Y.C. Lee. 2008. Patterns, Effects, and Thoracic Volume Changes of Thoracoscopic Pleurodesis in Rabbits. J. of Surgical Research 147:34-40.

Chang, C.W., H.Y. Chou, Y.S. Lin, K.H. Huang, C.J. Chang, T.C. Hsu, S.C. Lee. 2008. Phosphorylation at Ser473 regulates heterochromatin protein 1 binding and corepressor function of TIF1beta/KAP1. BMC Mol. Biol. 9:61

Birch J.L., B.C.M. Tan, K.I. Panov, T.B. Panova, Andersen J.S., T.A. Owen-Hughes, J. Russell, S.C. Lee, J.C. Zomerdijk. 2009. FACT facilitates chromatin transcription by RNA polymerase I and III. EMBO J. 28(7):854-865.

Chang, T.J., W.P. Chen, C. Yang, P.H. Lu, Y.C. Liang, M.J. Su, S.C. Lee, L.M. Chuang. 2009. Serine-385 phosphorylation of inwardly rectifying K+ channel subunit (Kir6.2) by AMP-dependent protein kinase plays a key role in rosiglitazone-induced closure of the KATP channel and insulin secretion in rats. Diabetologia 52:1112-1121.

Chen, Y.J., B.C. Tan, Y.Y. Cheng, J.S. Chen, S.C. Lee. 2010. Differential regulation of CHOP translation by phosphorylated eIF4E under stress conditions. Nucleic Acids Res. 38(3):764-777.

Li, A., Y. Yu, S.C. Lee, T. Ishibashi, S.P. Lees-Miller, J. Ausió. 2010. Phosphorylation of Histone H2A.X by DNA-dependent Protein Kinase Is Not Affected by Core Histone Acetylation, but It Alters Nucleosome Stability and Histone H1 Binding. J Biol Chem. 285(23):17778-88.
Tan, B.C., H. Liu , C.L. Lin , S.C. Lee. 2010. Functional cooperation between FACT and MCM is coordinated with cell cycle and differential complex formation. J Biomed Sci. 17:11.

Yang, K.T., S.K. Li , C.C. Chang , C.J. Tang , Y.N. Lin , S.C. Lee, T.K. Tang . 2010. Aurora-C Kinase Deficiency Causes Cytokinesis Failure in Meiosis I and Production of Large Polyploid Oocytes in Mouse. Mol Biol Cell. 21:2371-2383.

Hsieh C.L., C.L. Lin, H. Liu, Y.J Chang, C.J. Shih,
C.Z. Zhong, S.C. Lee, Bertrand Tan. 2011. WDHD1 modulates the post-transcriptional step of the centromeric silencing pathway. Nucleic Acids Res. 39(10):4048-62.

Lee K.J., Y.F. Lin, H.Y. Chou, H. Yajima, K.R. Fattah, S.C. Lee, and B.P.C. Chen. 2011. Involvement of DNA dependent protein kinase in normal cell cycle progression through mitosis. J. Biol. Chem. 286(14):12796-802.

White D, I.U. Rafalska-Metcalf, A.V. Ivanov, A . Corsinotti, H .Peng, S.C . Lee, D . Trono, S.M . Janicki, F.J. Rauscher 3rd. 2011. The ATM substrate KAP1 controls DNA repair in heterochromatin: Regulation by HP1 proteins and Serine 473/824 phosphorylation. Mol Cancer Res. 2012 Mar;10(3):401-14. Epub 2011 Dec 28.

Chou HY, T.H. Wang, S.C. Lee, P.H. Hsu, M.D. Tsai, C.L. Chang, Y.M. Jeng. 2011. Phosphorylation of NuSAP by Cdk1 regulates its interaction with microtubules in mitosis. Cell Cycle. 2011 Dec 1;10(23):4083-9.

Lee HC, Y.J. Chen, Y.W. Liu, K.Y. Lin, S.W. Chen, C.Y. Lin, Y.C. Lu, P.C. Hsu, S.C. Lee, H.J. Tsai. 2011. Transgenic zebrafish model to study translational control mediated by upstream open reading frame of human chop gene. Nucleic Acids Res. 2011 Nov 1;39(20):e139.

Chen HW, Yang CC, Hsieh CL, Liu H, Lee SC, Tan BC. A functional genomic approach reveals the transcriptional role of EDD in the expression and function of angiogenesis regulator ACVRL1. Biochim Biophys Acta. 2013 Dec;1829(12):1309-19. doi: 10.1016/j.bbagrm.2013.10.006. Epub 2013 Nov 2.

Yang FC, Lin YH, Chen WH, Huang JY, Chang HY, Su SH, Wang HT, Chiang CY, Hsu PH, Tsai MD, Tan BC, Lee SC. Interaction between salt-inducible kinase 2 (SIK2) and p97/valosin-containing protein (VCP) regulates endoplasmic reticulum (ER)-associated protein degradation in mammalian cells. J Biol Chem. 2013 Nov 22;288(47):33861-72. doi: 10.1074/jbc.M113.492199. Epub 2013 Oct 15.

Chiang PY, Shen YF, Su YL, Kao CH, Lin NY, Hsu PH, Tsai MD, Wang SC, Chang GD, Lee SC, Chang CJ. Phosphorylation of mRNA decapping protein Dcp1a by the ERK signaling pathway during early differentiation of 3T3-L1 preadipocytes. PLoS One. 2013 Apr 18;8(4):e61697. doi: 10.1371/journal.pone.0061697. Print 2013.

Yang FC, Tan BC, Chen WH, Lin YH, Huang JY, Chang HY, Sun HY, Hsu PH, Liou GG, Shen J, Chang CJ, Han CC, Tsai MD, Lee SC. Reversible acetylation regulates salt-inducible kinase (SIK2) and its function in autophagy. J Biol Chem. 2013 Mar 1;288(9):6227-37. doi: 10.1074/jbc.M112.431239. Epub 2013 Jan 15.

Tsai YC, Tsai SH, Chang EY, Hee SW, Chen WH, Lee SC, Chuang LM. Cytoskeletal protein vimentin interacts with and regulates peroxisome proliferator-activated receptor gamma via a proteasomal degradation process. J Cell Biochem. 2013 Jul;114(7):1559-67. doi: 10.1002/jcb.24497.

Chen YL, Jiang YW, Su YL, Lee SC, Chang MS, Chang CJ. Transcriptional regulation of tristetraprolin by NF-κB signaling in LPS-stimulated macrophages. Mol Biol Rep. 2013 Apr;40(4):2867-77. doi: 10.1007/s11033-012-2302-8. Epub 2012 Dec 1.