Chun-Liang Pan MD, Ph.D.
Professor and Director
Basic Medicine Building 1524
Tel：886-2-23123456 ext. 288360 (office) or 288358 (lab)
Neural basis of learning and behavioral plasticity
We are actively studying the genetic and neural circuit basis of animal behavior and learning, especially behavioral plasticity induced by stress and changes in the internal states. We employ molecular genetics, calcium imaging, high-throughput transcriptome (RNA-seq) and quantitative behavioral assays to dissect and genetic and circuit mechanisms that modify animal learning and behavior in response to physiological stress and internal states. Such mechanistic understanding is crucial to gain new insights into higher-order brain functions and cognitive impairment under pathological conditions.
Cell biology of neuronal aging.
The molecular mechanisms leading to the dismantling of apoptotic cells and injured neurons during development had been studied in detail. However, our understanding of the cell biological events occurring in the process of neuronal aging is far from clear. Work from our lab suggest that C. elegans neurons and mitochondria undergo characteristic morphological changes in senescence (PNAS 2011, PNAS 2015). Recently we collaborated with the lab of Ikue Mori to investigate the functional property of neurons during aging (Aging Cell 2020). We are now using various genetic and cell biological approaches to investigate how these events are regulated at the molecular and organelle level.
Neural Regulation of Mitochondrial Physiology and Stress Response
We are very interested in mitochondrial biology, how it impacts neuronal functions and aging at the organismal level. A recent notion emerging mainly through works in C. elegans establishes the nervous system as a key element in the coordination of systemic stress responses. We are particularly interested in the signals as well as the synaptic mechanisms that mediate the crosstalk between neurons and their target tissues in terms of stress response and physiological homeostasis (paper under revision).
Regulation of systemic physiology and longevity by the nervous system.
The nervous system in C. elegans, as that in more complex organisms, plays a critical role in maintaining systemic homeostasis of physiology. Our recent work shows that the thermosensory neuronal circuit controls C. elegans longevity through a secreted neuropeptide (Dev Cell 2016). C. elegans has a conserved panel of neurotransmitters (ACh, GABA, glutamate, dopamine, 5HT, octopamine, tyramine) and an unusually rich repertoire of neuropeptides, with only a handful being functionally characterized. We are in the process of deciphering the molecular and circuit mechanisms through which neurons exert cell non-autonomous regulation of physiology and aging in distal tissues.
- 1989-1996 M.D., National Taiwan University, Taiwan
- 2003-2008 Ph.D., Helen Wills Neuroscience Institute, University of California, Berkeley, USA
- 2019- Professor and Director, Graduate Institute of Molecular Medicine; Deputy director, R&D Branch Office, School of Medicine, National Taiwan University, Taiwan
- 2015-2019 Associate Professor, Graduate Institute of Molecular Medicine, School of Medicine, National Taiwan University, Taiwan
- 2010-2015 Assistant Professor, Graduate Institute of Molecular Medicine, School of Medicine, National Taiwan University, Taiwan
- 2008-2010 Postdoctoral Fellow, Ernest Gallo Clinic and Research Center, University of California, San Francisco, USA
- 2002-2003 Research Assistant, Institute of Biological Chemistry, Academia Sinica, Taiwan
- 1998-2002 Resident, Department of Neurology, National Taiwan University Hospital, Taiwan
吳毓純 (交通大學；2018- 直升)
徐均旻 (清華大學；2012畢，2015-2020美國Oregon Health & Science University博士；2020- 史丹福大學博士後研究)
陳彥志 (中興大學；2013畢，2016- 美國紐約大學博士班生)
姜浩菁 (台灣大學；2014畢，2017- 美國麻州大學博士班生)
陳忠寬 (台灣大學；2014畢，2018- 日本筑波大學博士班生)
陳虹蓁 (陽明大學；2015畢，2016- 美國南加大博士班生)
何俊緯 (清華大學；2016畢，2019- 美國加州大學戴維斯分校博士班生)
Edward Hsieh (2014，美國杜克大學畢業)
Lawrence Chen (2019，美國芝加哥大學)
Jason Leu (2020)
- Pan CL. (2022) May the Force Be with You: Mechanosensitivity Shapes Dendrite Development. (invited preview) Developmental Cell 57: 1561-1562.
- Chen CK, Pan CL.* (2022) Cell Polarity Control by Wnt Morphogens. (invited review) Developmental Biology 487: 34-41.
- Chiang YC, Liao CP, Pan CL*. (2022) A Serotonergic Circuit Regulates Aversive Associative Learning under Mitochondrial Stress in C. elegans. Proceedings of the National Academy of Sciences USA 119: e2115533119.
- Chou SH, Chen YJ, Liao CP, Pan CL*. (2022) A Role for Dopamine in C. elegans Avoidance Behavior Induced by Mitochondrial Stress. Neuroscience Research 178: 87-92.
- Chen LT, Lin CT, Lin LY, Hsu JM, Wu YC, Pan CL.* (2021) Neuronal mitochondrial dynamics coordinate systemic mitochondrial morphology and stress response to confer pathogen resistance in C. elegans. Developmental Cell 56: 1770-1785
- Chen CH* and Pan CL.* (2021) Live-cell imaging of PVD dendrite growth cone in post-embryonic C. elegans. STAR Protocols 2: 100402
- Wu YC, Chiang YC, Chou SH, Pan CL. (2021) Wnt signaling and endocytosis: mechanisms, controversies and implications for stress responses (invited review). Biol Cell 113: 95-106. doi:10.1111/boc.202000099 online ahead of print
- Hsu HW, Liao CP, Chiang YC, Syu RT, Pan CL. (2020) C. elegans Flamingo FMI-1 Controls Dendrite Self-Avoidance through F-Actin Assembly. Development 147(14):dev179168. doi:10.1242/dev.179168.
- Huang TT, Matsuyama H, Tsukada Y, Singhvi A, Syu RT, Lu Y, Shaham S, Mori I*, Pan CL*. (2020) Age-Dependent Changes in Response Property and Morphology of A Thermosensory Neuron and Thermotaxis Behavior in Caenorhabditis elegans. Aging Cell DOI:10.1111/acel.13146 (* co-correspondence)
- Chen CH, Hsu HW, Chang YH, Pan CL. (2019) Adhesive LICAM-Robo Signaling Aligns Growth Cone F-Actin Dynamics to Promote Axon-Dendrite fasciculation in C. elegans. Developmental Cell 48: 215-228 (recommended by FB1000)
- He CW, Liao CP, Chen CK, Teulière J, Chen CH, Pan CL. (2018). The polarity protein VANG-1 antagonizes Wnt signaling by facilitating Frizzled endocytosis. Development pii: dev.168666. doi: 10.1242/dev.168666.
- He CW, Liao CP, Pan CL. (2018) Wnt Signalling in the Development of Axon, Dendrites and Synapses. (invited review) Open Biology 8: 180116.
- Liao CP, Li H, Lee HH, Chien CT, Pan CL. (2018) Cell-Autonomous Regulation of Dendrite Self-Avoidance by the Wnt Secretory Factor MIG-14/Wntless. Neuron 98: 320-334. (previewed by Neuron)
- Lin CT, He CW, Huang TT, Pan CL. (2017) Longevity Control by the Nervous System: Sensory Perception, Stress Response and Beyond. (invited review) Translational Medicine of Aging 1: 41-51.
- Chen CH, He CW, Liao CP, Pan CL. (2017) A Wnt-Planar Polarity Pathway instructs Neurite Branching by Restricting F-Actin Assembly through Endosomal Signaling. PLOS Genetics 13: e1006720
- Chen YC, Chen HJ, Tseng WC, Hsu JM, Huang TT, Chen CH, Pan CL. (2016) A C. elegans Thermosensory Circuit Regulates Longevity through crh-1/CREB-Dependent flp-6 Neuropeptide Signaling. Developmental Cell 39: 209-223. (previewed by Developmental Cell and Science Signaling)
- Jiang HC, Hsu JM, Yen CP, Chao CC, Chen RH, Pan CL. (2015) Neural Activity and CaMKII Protect Mitochondria from Fragmentation in Aging C. elegans Neurons. Proceedings of the National Academy of Sciences USA. 112: 8768-8773.
- Hsu JM, Chen CH, Chen YC, McDonald KL, Gurling M, Lee A, Garriga G, Pan CL. (2014) Genetic Analysis of A Novel Tubulin Mutation That Redirects Synaptic Vesicle Targeting and Causes Neurite Degeneration in C. elegans. PLOS Genetics 10: e1004715.
- Chen CH, Lee A, Liao CP, Liu YW, Pan CL. (2014) RHGF-1/PDZ-RhoGEF and Retrograde DLK-1 Signaling Drive Neuronal Remodeling on Microtubule Disassembly. Proceedings of the National Academy of Sciences USA. 111: 16568-16573.
- Pan CL, Peng CY, Chen CH, McIntire SL. (2011) Genetic analysis of age-dependent defects of C. elegans touch receptor neurons. Proceedings of the National Academy of Sciences USA. 108: 9274-9279 (recommended by FB1000)
- Pan CL, and Garriga G. (2008) Fresh air is good for nerves: hypoxia disturbs axon guidance. Nature Neuroscience 11: 859-861.
- Pan CL, Baum PD, Gu M, Jorgensen EM, Clark SG, Garriga G. (2008) C. elegans AP-2 and retromer control Wnt secretion by regulating MIG-14/Wntless. Developmental Cell 14: 132-139 (highlighted in Developmental Cell and Nature Review Molecular Cell Biology)
- Pan CL, Howell JE, Clark SG, Hilliard MA, Cordes S, Bargmann CI, Garriga G. (2006) Multiple Wnts and Frizzled receptors regulate anteriorly directed cell and growth cone migrations in Caenorhabditis elegans. Developmental Cell 10: 367-377 (highlighted in Neuron and recommended by FB1000)
- Pan CL, Kuo MF, Hsieh ST. (2004) Auditory agnosia caused by a tectal germinoma. Neurology 63: 2387-2389.
- Pan CL, Shun CT, Susuki K, Yuki N, Hsieh ST. (2004) Pharyngeal-brachial palsy after cytomegalovirus colitis. Neurology 62:153-154 (highlight article)
- Pan CL, Tseng TJ, Lin YH, Chiang MC, Lin WM, Hsieh ST. (2003) Cutaneous innervation in Guillain-Barré syndrome: pathology and clinical correlations. Brain 126:386-397.
- Pan CL, Yuki N, Koga M, Chiang MC, Hsieh ST. (2001) Acute sensory ataxic neuropathy associated with monospecific anti-GD1b IgG antibody. Neurology 57: 1316-1318.
- Pan CL, Lin YH, Lin WM, Tai TY, Hsieh ST. (2001) Degeneration of nociceptive nerve terminals in human peripheral neuropathy. Neuroreport 12: 787-792.